Alex Azar serves as the United States Secretary of Health and Human Services, having been Deputy Secretary from 2005 to 2007. He was nominated by President Donald Trump on November 13, 2017, and confirmed by the Senate on January 24, 2018

Preetinder Bharara served as the United States Attorney for the Southern District of New York from 2009 to 2017. According to The New York Times, during his tenure he was one of "the nation's most aggressive and outspoken prosecutors of public corruption and Wall Street crime." On April 1, 2017, Bharara joined the New York University School of Law faculty as a Distinguished Scholar in Residence.

Christina Freeland is a Canadian writer, journalist, and politician who is serving as the tenth Deputy Prime Minister of Canada and thirteenth Minister of Intergovernmental Affairs since 2019. She served as Canada's Minister of Foreign Affairs from 2017 to 2019, and Minister of International Trade from 2015 to 2017.

Nancy Goroff is a Professor of Chemistry at SUNY Stony Brook. She also served as chair of the Chemistry Department, Associate Dean of the Graduate School, and Associate Provost for the Integration of Research, Education, and Professional Development.

She has taken a leave from her academic position to run for the U.S. House to represent New York's 1st Congressional District. She declared candidacy for the Democratic primary scheduled on June 23, 2020.

Lucy Koh is a United States District Judge of the United States District Court for the Northern District of California and is a former nominee to be a United States Circuit Judge of the United States Court of Appeals for the Ninth Circuit.

Kyriakos Mitsotakis is a Greek politician serving as Prime Minister of Greece since 8 July 2019. A member of New Democracy, he has been its president since 2016. He previously was Leader of the Opposition from 2016 to 2019 and Minister of Administrative Reform from 2013 to 2015.

Lisa Monaco was the Homeland Security Adviser to President Barack Obama; the chief counterterrorism advisor to the President, and a statutory member of the United States Homeland Security Council.

She previously served as the Assistant Attorney General for National Security from 2011 to 2013, and as the Principal Deputy Assistant Attorney General in the Justice Department.

In 2017, Monaco became a senior national security analyst for CNN.

Jessie Steigerwald serves on the Lexington School Committee.